| First Author | Cobos I | Year | 2006 |
| Journal | Cereb Cortex | Volume | 16 Suppl 1 |
| Pages | i82-8 | PubMed ID | 16766712 |
| Mgi Jnum | J:154438 | Mgi Id | MGI:4368026 |
| Doi | 10.1093/cercor/bhk003 | Citation | Cobos I, et al. (2006) Cellular patterns of transcription factor expression in developing cortical interneurons. Cereb Cortex 16 Suppl 1:i82-8 |
| abstractText | Most gamma-aminobutyric acidergic interneurons in the neocortex and hippocampus are derived from subpallial progenitors in the medial ganglionic eminence and migrate tangentially to the pallium, where they differentiate into a diverse set of neuronal subtypes. Toward elucidating the mechanisms underlying the generation of interneuron diversity, we have studied in mice the expression patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB). Their patterns of expression change during interneuron differentiation and show distinct distributions within interneuron subpopulations in adult neocortex. This study is a first step to define the combinatorial codes of transcription factors that participate in regulating the specification and function of cortical interneuron subtypes. |
