| First Author | Feng JM | Year | 2006 |
| Journal | Immunity | Volume | 24 |
| Issue | 6 | Pages | 717-27 |
| PubMed ID | 16782028 | Mgi Jnum | J:113366 |
| Mgi Id | MGI:3665520 | Doi | 10.1016/j.immuni.2006.04.007 |
| Citation | Feng JM, et al. (2006) Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity 24(6):717-27 |
| abstractText | Calcium influx is crucial for T cell activation and differentiation. The detailed regulation of this process remains unclear. We report here that golli protein, an alternatively spliced product of the myelin basic protein gene, plays a critical role in regulating calcium influx in T cells. Golli-deficient T cells were hyperproliferative and showed enhanced calcium entry upon T cell receptor stimulation. We further found that golli regulates calcium influx in T cells through the inhibition of the store depletion-induced calcium influx. Mutation of the myristoylation site on golli disrupted its association with the plasma membrane and reversed its inhibitory action on Ca2+ influx, indicating that membrane association of golli was essential for its inhibitory action. These results indicate that golli functions in a unique way to regulate T cell activation through a mechanism involving the modulation of the calcium homeostasis. |
