| First Author | Hikida T | Year | 2008 |
| Journal | Biol Psychiatry | Volume | 63 |
| Issue | 10 | Pages | 997-1000 |
| PubMed ID | 18191108 | Mgi Jnum | J:139611 |
| Mgi Id | MGI:3808964 | Doi | 10.1016/j.biopsych.2007.09.025 |
| Citation | Hikida T, et al. (2008) Modulation of D-serine levels in brains of mice lacking PICK1. Biol Psychiatry 63(10):997-1000 |
| abstractText | BACKGROUND: D-serine is an endogenous coagonist of the N-methyl-D-aspartate subtype glutamate receptor. Genetic association studies have implicated genes coding for enzymes associated with D-serine metabolism in schizophrenia and bipolar disorder. METHODS: Protein expression of serine racemase (SR) and its binding partner, protein interacting with C-kinase (PICK1), were examined by Western blotting in brains from wildtype and PICK1 knockout mice. Levels of D-serine in wildtype and PICK1 mice were also examined by an established high-pressure liquid chromatography protocol. RESULTS: Expression of SR and PICK1 proteins was developmentally regulated. Although no change was observed in the level of SR protein, levels of D-serine were selectively decreased in the forebrain of neonatal PICK1 knockout mice, compared with those in wildtype mice. CONCLUSIONS: PICK1 may be involved in the regulation of brain D-serine levels and SR in a spatially and temporally specific manner. |
