| First Author | Yang H | Year | 2016 |
| Journal | Nat Neurosci | Volume | 19 |
| Issue | 1 | Pages | 127-34 |
| PubMed ID | 26642088 | Mgi Jnum | J:358663 |
| Mgi Id | MGI:6212158 | Doi | 10.1038/nn.4183 |
| Citation | Yang H, et al. (2016) Origins of choice-related activity in mouse somatosensory cortex. Nat Neurosci 19(1):127-34 |
| abstractText | During perceptual decisions about faint or ambiguous sensory stimuli, even identical stimuli can produce different choices. Spike trains from sensory cortex neurons can predict trial-to-trial variability in choice. Choice-related spiking is widely studied as a way to link cortical activity to perception, but its origins remain unclear. Using imaging and electrophysiology, we found that mouse primary somatosensory cortex neurons showed robust choice-related activity during a tactile detection task. Spike trains from primary mechanoreceptive neurons did not predict choices about identical stimuli. Spike trains from thalamic relay neurons showed highly transient, weak choice-related activity. Intracellular recordings in cortex revealed a prolonged choice-related depolarization in most neurons that was not accounted for by feed-forward thalamic input. Top-down axons projecting from secondary to primary somatosensory cortex signaled choice. An intracellular measure of stimulus sensitivity determined which neurons converted choice-related depolarization into spiking. Our results reveal how choice-related spiking emerges across neural circuits and within single neurons. |
