| First Author | Lyons-Warren AM | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 12 | Pages | 113471 |
| PubMed ID | 37980561 | Mgi Jnum | J:343332 |
| Mgi Id | MGI:7565207 | Doi | 10.1016/j.celrep.2023.113471 |
| Citation | Lyons-Warren AM, et al. (2023) Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination. Cell Rep 42(12):113471 |
| abstractText | Co-transmission of multiple neurotransmitters from a single neuron increases the complexity of signaling information within defined neuronal circuits. Superficial short-axon cells in the olfactory bulb release both dopamine and gamma-aminobutyric acid (GABA), yet the specific targets of these neurotransmitters and their respective roles in olfaction have remained unknown. Here, we implement intersectional genetics in mice to selectively block GABA or dopamine release from superficial short-axon cells to identify their distinct cellular targets, impact on circuit function, and behavioral contribution of each neurotransmitter toward olfactory behaviors. We provide functional and anatomical evidence for divergent superficial short-axon cell signaling onto downstream neurons to shape patterns of mitral cell firing that contribute to olfactory-related behaviors. |
