| First Author | Yang SH | Year | 2008 |
| Journal | Biochim Biophys Acta | Volume | 1781 |
| Issue | 1-2 | Pages | 36-9 |
| PubMed ID | 18082640 | Mgi Jnum | J:133416 |
| Mgi Id | MGI:3778551 | Doi | 10.1016/j.bbalip.2007.11.003 |
| Citation | Yang SH, et al. (2008) Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. Biochim Biophys Acta 1781(1-2):36-9 |
| abstractText | Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid syndrome characterized by multiple aging-like disease phenotypes. We recently reported that a protein farnesyltransferase inhibitor (FTI) improved several disease phenotypes in mice with a HGPS mutation (Lmna(HG/+)). Here, we investigated the impact of an FTI on the survival of Lmna(HG/+) mice. The FTI significantly improved the survival of both male and female Lmna(HG/+) mice. Treatment with the FTI also improved body weight curves and reduced the number of spontaneous rib fractures. This study provides further evidence for a beneficial effect of an FTI in HGPS. |
