| First Author | Park MJ | Year | 2022 |
| Journal | Endocrinol Metab (Seoul) | Volume | 37 |
| Issue | 3 | Pages | 552-557 |
| PubMed ID | 35798554 | Mgi Jnum | J:334583 |
| Mgi Id | MGI:7461363 | Doi | 10.3803/EnM.2022.1421 |
| Citation | Park MJ, et al. (2022) Sestrin2 Regulates Beneficial beta3-Adrenergic Receptor-Mediated Effects Observed in Inguinal White Adipose Tissue and Soleus Muscle. Endocrinol Metab (Seoul) 37(3):552-557 |
| abstractText | Sestrin2, a well-known adenosine monophosphate-activated protein kinase (AMPK) regulator, plays a protective role against metabolic stress. The beta3-adrenergic receptor (beta3AR) induces fat browning and inhibits muscle atrophy in an AMPK-dependent manner. However, no prior research has examined the relationship of sestrin2 with beta3AR in body composition changes. In this study, CL 316,243 (CL), a beta3AR agonist, was administered to wild-type and sestrin2-knockout (KO) mice for 2 weeks, and fat and muscle tissues were harvested. CL induced AMPK phosphorylation, expression of brown-fat markers, and mitochondrial biogenesis, which resulted in the reduction of lipid droplet size in inguinal white adipose tissue (iWAT). These effects were not observed in sestrin2-KO mice. In CL-treated soleus muscle, sestrin2-KO was related to decreased myogenic gene expression and increased levels of muscle atrophy-related molecules. Our results suggest that sestrin2 is associated with beneficial beta3AR-mediated changes in body composition, especially in iWAT and in the soleus. |
