Primary Identifier | MGI:3589207 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Apc |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | LoxP sites were inserted to flank exons 11 and 12. Cre-mediated deletion of these exons would result in the out-of-frame splicing of exon 10 to exon 13 and the generation of a prematurely terminated 468-amino acid protein. This mutant protein would be shorter than most truncated Apc proteins. |