| First Author | Hou XH | Year | 2016 |
| Journal | Cell | Volume | 167 |
| Issue | 1 | Pages | 73-86.e12 |
| PubMed ID | 27662084 | Mgi Jnum | J:253211 |
| Mgi Id | MGI:6109235 | Doi | 10.1016/j.cell.2016.08.073 |
| Citation | Hou XH, et al. (2016) Central Control Circuit for Context-Dependent Micturition. Cell 167(1):73-86.e12 |
| abstractText | Urine release (micturition) serves an essential physiological function as well as a critical role in social communication in many animals. Here, we show a combined effect of olfaction and social hierarchy on micturition patterns in adult male mice, confirming the existence of a micturition control center that integrates pro- and anti-micturition cues. Furthermore, we demonstrate that a cluster of neurons expressing corticotropin-releasing hormone (Crh) in the pontine micturition center (PMC) is electrophysiologically distinct from their Crh-negative neighbors and sends glutamatergic projections to the spinal cord. The activity of PMC Crh-expressing neurons correlates with and is sufficient to drive bladder contraction, and when silenced impairs micturition behavior. These neurons receive convergent input from widespread higher brain areas that are capable of carrying diverse pro- and anti-micturition signals, and whose activity modulates hierarchy-dependent micturition. Taken together, our results indicate that PMC Crh-expressing neurons are likely the integration center for context-dependent micturition behavior. |
