| Primary Identifier | MGI:3589475 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(PRNP-APPSweInd)8Dwst |
| Strain of Origin | (C3H/HeJ x C57BL/6J)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene expresses the mutant human amyloid protein precursor APPSweInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the Syrian hamster prion protein promoter. Transgenic mice express the App protein in brain at approximately 5 times the level of control mice. High level production of the pathogenic Abeta42 form of the Abeta peptide is seen by three months of age. |
