|  Help  |  About  |  Contact Us

Publication : Quantitative trait Loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model.

First Author  Kim EH Year  2005
Journal  Exp Anim Volume  54
Issue  4 Pages  319-25
PubMed ID  16093645 Mgi Jnum  J:100490
Mgi Id  MGI:3588624 Doi  10.1538/expanim.54.319
Citation  Kim EH, et al. (2005) Quantitative trait Loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model. Exp Anim 54(4):319-25
abstractText  In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located on chromosomes (Chrs) 8 and 10, a kidney weight QTL (Kdw1) on Chr 19, and a body weight QTL (Bdw1) on Chr 13 were detected at the genome-wide 5% or less level. The allele derived from FGS/Kist increased GSI at Gsi1, but decreased it at Gsi2. The mice homozygous for the FGS/Kist allele decreased body and kidney weights. The identified QTLs accounted for 5-8% of the phenotypic variance.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

23 Bio Entities

Trail: Publication

0 Expression