| First Author | Furusawa T | Year | 2009 |
| Journal | Gene Expr Patterns | Volume | 9 |
| Issue | 5 | Pages | 289-95 |
| PubMed ID | 19303948 | Mgi Jnum | J:148798 |
| Mgi Id | MGI:3846499 | Doi | 10.1016/j.gep.2009.03.002 |
| Citation | Furusawa T, et al. (2009) Expression of nucleosomal protein HMGN1 in the cycling mouse hair follicle. Gene Expr Patterns 9(5):289-95 |
| abstractText | Here we examine the expression pattern of HMGN1, a nucleosome binding protein that affects chromatin structure and activity, in the hair follicle and test whether loss of HMGN1 affects the development or cycling of the follicle. We find that at the onset of hair follicle development, HMGN1 protein is expressed in the epidermal placode and in aggregated dermal fibroblasts. In the adult hair follicle, HMGN1 is specifically expressed in the basal layer of epidermis, in the outer root sheath, in the hair bulb, but not in the inner root sheath and hair shaft. The expression pattern of HMGN1 is very similar to p63, suggesting a role for HMGN1 in the transiently amplifying cells. We also find HMGN1 expression in some, but not all hair follicle stem cells as detected by its colocalization with Nestin and with BrdU label-retaining cells. The appearance of the skin and hair follicle of Hmgn1(-/-) mice was indistinguishable from that of their Hmgn1(+/+) littermates. We found that in the hair follicle the expression of HMGN2 is very similar to HMGN1 suggesting functional redundancy between these closely related HMGN variants. |
