| First Author | Sturgill JF | Year | 2015 |
| Journal | Nat Neurosci | Volume | 18 |
| Issue | 4 | Pages | 531-5 |
| PubMed ID | 25751531 | Mgi Jnum | J:358665 |
| Mgi Id | MGI:6213814 | Doi | 10.1038/nn.3971 |
| Citation | Sturgill JF, et al. (2015) Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex. Nat Neurosci 18(4):531-5 |
| abstractText | Diverse types of local GABAergic interneurons shape the cortical representation of sensory information. Here we show how somatostatin-expressing interneurons (SOM cells) contribute to odor coding in mouse olfactory cortex. We find that odor-tuned SOM cells regulate principal cells through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning. SOM cells inhibit both principal cells and fast-spiking interneurons, indicating that subtractive inhibition reflects the interplay of multiple classes of interneurons. |
