| First Author | Cohen-Kashi Malina K | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 12740 | PubMed ID | 27615520 |
| Mgi Jnum | J:358657 | Mgi Id | MGI:6208779 |
| Doi | 10.1038/ncomms12740 | Citation | Cohen-Kashi Malina K, et al. (2016) Local and thalamic origins of correlated ongoing and sensory-evoked cortical activities. Nat Commun 7:12740 |
| abstractText | Thalamic inputs of cells in sensory cortices are outnumbered by local connections. Thus, it was suggested that robust sensory response in layer 4 emerges due to synchronized thalamic activity. To investigate the role of both inputs in the generation of correlated cortical activities, we isolated the thalamic excitatory inputs of cortical cells by optogenetically silencing cortical firing. In anaesthetized mice, we measured the correlation between isolated thalamic synaptic inputs of simultaneously patched nearby layer 4 cells of the barrel cortex. Here we report that in contrast to correlated activity of excitatory synaptic inputs in the intact cortex, isolated thalamic inputs exhibit lower variability and asynchronous spontaneous and sensory-evoked inputs. These results are further supported in awake mice when we recorded the excitatory inputs of individual cortical cells simultaneously with the local field potential in a nearby site. Our results therefore indicate that cortical synchronization emerges by intracortical coupling. |
