| First Author | McNamara CG | Year | 2014 |
| Journal | Nat Neurosci | Volume | 17 |
| Issue | 12 | Pages | 1658-60 |
| PubMed ID | 25326690 | Mgi Jnum | J:358661 |
| Mgi Id | MGI:6210908 | Doi | 10.1038/nn.3843 |
| Citation | McNamara CG, et al. (2014) Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. Nat Neurosci 17(12):1658-60 |
| abstractText | We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence. |
