| First Author | Lévesque M | Year | 2021 |
| Journal | Curr Res Neurobiol | Volume | 2 |
| Pages | 100008 | PubMed ID | 36246508 |
| Mgi Jnum | J:360927 | Mgi Id | MGI:7850870 |
| Doi | 10.1016/j.crneur.2021.100008 | Citation | Levesque M, et al. (2021) Evolution of interictal spiking during the latent period in a mouse model of mesial temporal lobe epilepsy. Curr Res Neurobiol 2:100008 |
| abstractText | Interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz) occur in epileptic patients and in animal models of mesial temporal lobe epilepsy (MTLE). In this study, we explored how type 1 and type 2 interictal spikes as well as ripples and fast ripples evolve during the latent period in the hippocampus of pilocarpine-treated mice. Depth EEG recordings were obtained from the hippocampus CA3 subfield of adult male mice (n = 5, P60-P100) starting one day before pilocarpine-induced status epilepticus up to the first spontaneous seizure, the so-called latent period. We found that rates of type 1 (n = 1 655) and type 2 (n = 2 309) interictal spikes were significantly lower during the late phase of the latent period compared to its early and mid phase (p < 0.001). However, rates of type 1 spikes associated with ripples (n = 266) or fast ripples (n = 106), as well as rates of type 2 interictal spikes associated with ripples (n = 233), were significantly higher during the late phase compared to the early and mid phases (p < 0.05). Our findings reveal that an increase of type 1 interictal spikes co-occurring with ripples or fast ripples and an increase of type 2 interictal spikes co-occurring with ripples mark the end of the latent period. We propose that changes in the occurrence of interictal spike associated with HFOs represent a biomarker of epileptogenicity in this mouse model of MTLE. |
