| First Author | Guzulaitis R | Year | 2022 |
| Journal | Nat Neurosci | Volume | 25 |
| Issue | 12 | Pages | 1683-1692 |
| PubMed ID | 36376483 | Mgi Jnum | J:358780 |
| Mgi Id | MGI:7486691 | Doi | 10.1038/s41593-022-01198-z |
| Citation | Guzulaitis R, et al. (2022) Neural basis of anticipation and premature impulsive action in the frontal cortex. Nat Neurosci 25(12):1683-1692 |
| abstractText | Planning motor actions can improve behavioral performance; however, it can also lead to premature actions. Although the anterior lateral motor cortex (ALM) is known to be important for correct motor planning, it is currently unknown how it contributes to premature impulsive motor output. This was addressed using whole-cell voltage recordings from layer 2/3 pyramidal neurons within the ALM while mice performed a cued sensory association task. Here, a robust voltage response was evoked during the auditory cue, which was greater during incorrect premature behavior than during correct performance in the task. Optogenetically suppressing ALM during the cued sensory association task led to enhanced behavior, with fewer, and more delayed, premature responses and faster correct responses. Taken together, our findings extend the current known roles of the ALM, illustrating that ALM plays an important role in impulsive behavior by encoding and influencing premature motor output. |
