| First Author | Jackson AD | Year | 2024 |
| Journal | Neuron | Volume | 112 |
| Issue | 7 | Pages | 1182-1195.e5 |
| PubMed ID | 38266646 | Mgi Jnum | J:346691 |
| Mgi Id | MGI:7614096 | Doi | 10.1016/j.neuron.2023.12.017 |
| Citation | Jackson AD, et al. (2024) Amygdala-hippocampus somatostatin interneuron beta-synchrony underlies a cross-species biomarker of emotional state. Neuron |
| abstractText | Emotional responses arise from limbic circuits including the hippocampus and amygdala. In the human brain, beta-frequency communication between these structures correlates with self-reported mood and anxiety. However, both the mechanism and significance of this biomarker as a readout vs. driver of emotional state remain unknown. Here, we show that beta-frequency communication between ventral hippocampus and basolateral amygdala also predicts anxiety-related behavior in mice, both on long timescales ( approximately 30 min) and immediately preceding behavioral choices. Genetically encoded voltage indicators reveal that this biomarker reflects synchronization between somatostatin interneurons across both structures. Indeed, synchrony between these neurons dynamically predicts approach-avoidance decisions, and optogenetically shifting the phase of synchronization by just 25 ms is sufficient to bidirectionally modulate anxiety-related behaviors. Thus, back-translation establishes a human biomarker as a causal determinant (not just predictor) of emotional state, revealing a novel mechanism whereby interregional synchronization that is frequency, phase, and cell type specific controls emotional processing. |
