| First Author | Li FR | Year | 2024 |
| Journal | Curr Res Neurobiol | Volume | 6 |
| Pages | 100131 | PubMed ID | 38812499 |
| Mgi Jnum | J:360563 | Mgi Id | MGI:7834539 |
| Doi | 10.1016/j.crneur.2024.100131 | Citation | Li FR, et al. (2024) Ictal activity is sustained by the estrogen receptor beta during the estrous cycle. Curr Res Neurobiol 6:100131 |
| abstractText | Catamenial epilepsy, defined as a periodicity of seizure exacerbation during the menstrual cycle, affects up to 70 % of epileptic women. Seizures in these patients are often non-responsive to medication; however, our understanding of the relation between menstrual cycle and seizure generation (i.e. ictogenesis) remains limited. We employed here field potential recordings in the in vitro 4-aminopyridine model of epileptiform synchronization in female mice (P60-P130) and found that: (i) the estrous phase favors ictal activity in the entorhinal cortex; (ii) these ictal discharges display an onset pattern characterised by the presence of chirps that are thought to mirror synchronous interneuron firing; and (iii) blocking estrogen receptor beta-mediated signaling reduces ictal discharge duration. Our findings indicate that the duration of 4AP-induced ictal discharges, in vitro, increases during the estrous phase, which corresponds to the human peri-ovulatory period. We propose that these effects are caused by the presumptive enhancement of interneuron excitability due to increased estrogen receptor beta-mediated signaling. |
