| First Author | Chamberland S | Year | 2023 |
| Journal | Neuron | Volume | 111 |
| Issue | 8 | Pages | 1264-1281.e5 |
| PubMed ID | 36787751 | Mgi Jnum | J:334629 |
| Mgi Id | MGI:7448340 | Doi | 10.1016/j.neuron.2023.01.017 |
| Citation | Chamberland S, et al. (2023) Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons. Neuron |
| abstractText | Neurons perform input-output operations that integrate synaptic inputs with intrinsic electrical properties; these operations are generally constrained by the brevity of synaptic events. Here, we report that sustained firing of CA1 hippocampal fast-spiking parvalbumin-expressing interneurons (PV-INs) can be persistently interrupted for several hundred milliseconds following brief GABA(A)R-mediated inhibition in vitro and in vivo. A single presynaptic neuron could interrupt PV-IN firing, occasionally with a single action potential (AP), and reliably with AP bursts. Experiments and computational modeling reveal that the persistent interruption of firing maintains neurons in a depolarized, quiescent state through a cell-autonomous mechanism. Interrupted PV-INs are strikingly responsive to Schaffer collateral inputs. The persistent interruption of firing provides a disinhibitory circuit mechanism favoring spike generation in CA1 pyramidal cells. Overall, our results demonstrate that neuronal silencing can far outlast brief synaptic inhibition owing to the well-tuned interplay between neurotransmitter release and postsynaptic membrane dynamics, a phenomenon impacting microcircuit function. |
