| First Author | Yu XD | Year | 2022 |
| Journal | Nat Neurosci | Volume | 25 |
| Issue | 12 | Pages | 1651-1663 |
| PubMed ID | 36446933 | Mgi Jnum | J:358961 |
| Mgi Id | MGI:7486698 | Doi | 10.1038/s41593-022-01200-8 |
| Citation | Yu XD, et al. (2022) Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety. Nat Neurosci 25(12):1651-1663 |
| abstractText | Anxiety-like behaviors in mice include social avoidance and avoidance of bright spaces. Whether these features are distinctly regulated is unclear. We demonstrate that in mice, social and anxiogenic stimuli, respectively, increase and decrease serotonin (5-HT) levels in basal amygdala (BA). In dorsal raphe nucleus (DRN), 5-HT intersectionvGluT3 neurons projecting to BA parvalbumin (DRN(5-HT intersectionvGluT3)-BA(PV)) and pyramidal (DRN(5-HT intersectionvGluT3)-BA(Pyr)) neurons have distinct intrinsic properties and gene expression and respond to anxiogenic and social stimuli, respectively. Activation of DRN(5-HT intersectionvGluT3)-->BA(PV) inhibits 5-HT release via GABA(B) receptors on serotonergic terminals in BA, inducing social avoidance and avoidance of bright spaces. Activation of DRN(5-HT intersectionvGluT3)-->BA neurons inhibits two subsets of BA(Pyr) neurons via 5-HT1A receptors (HTR1A) and 5-HT1B receptors (HTR1B). Pharmacological inhibition of HTR1A and HTR1B in BA induces avoidance of bright spaces and social avoidance, respectively. These findings highlight the functional significance of heterogenic inputs from DRN to BA subpopulations in the regulation of separate anxiety-related behaviors. |
