| First Author | Stujenske JM | Year | 2022 |
| Journal | Neuron | Volume | 110 |
| Issue | 14 | Pages | 2258-2267.e11 |
| PubMed ID | 35397211 | Mgi Jnum | J:330688 |
| Mgi Id | MGI:7327019 | Doi | 10.1016/j.neuron.2022.03.020 |
| Citation | Stujenske JM, et al. (2022) Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons. Neuron 110(14):2258-2267.e11 |
| abstractText | The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate discrimination of a non-threatening stimulus is unknown. Here, we show that somatostatin (SOM) interneurons in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues and desynchronize cell firing by blocking phase reset of theta oscillations during the safe cue. Furthermore, we show that SOM activation and desynchronization of the BLA is PL-dependent and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM responses to non-threatening stimuli. |
