| First Author | Yang W | Year | 2022 |
| Journal | Nat Neurosci | Volume | 25 |
| Issue | 10 | Pages | 1339-1352 |
| PubMed ID | 36171427 | Mgi Jnum | J:344022 |
| Mgi Id | MGI:7486709 | Doi | 10.1038/s41593-022-01171-w |
| Citation | Yang W, et al. (2022) Thalamus-driven functional populations in frontal cortex support decision-making. Nat Neurosci 25(10):1339-1352 |
| abstractText | Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and cognitive variables during decision-making. The neural circuit basis for this complex selectivity remains unclear. We examined activity mediating a tactile decision in mouse anterior lateral motor cortex in relation to the underlying circuits. Contrary to the notion of randomly mixed selectivity, an analysis of 20,000 neurons revealed organized activity coding behavior. Individual neurons exhibited prototypical response profiles that were repeatable across mice. Stimulus, choice and action were coded nonrandomly by distinct neuronal populations that could be delineated by their response profiles. We related distinct selectivity to long-range inputs from somatosensory cortex, contralateral anterior lateral motor cortex and thalamus. Each input connects to all functional populations but with differing strength. Task selectivity was more strongly dependent on thalamic inputs than cortico-cortical inputs. Our results suggest that the thalamus drives subnetworks within frontal cortex coding distinct features of decision-making. |
