| First Author | Huang P | Year | 2020 |
| Journal | Cell Rep | Volume | 33 |
| Issue | 8 | Pages | 108415 |
| PubMed ID | 33238116 | Mgi Jnum | J:301681 |
| Mgi Id | MGI:6489173 | Doi | 10.1016/j.celrep.2020.108415 |
| Citation | Huang P, et al. (2020) Somatostatin Neurons Govern Theta Oscillations Induced by Salient Visual Signals. Cell Rep 33(8):108415 |
| abstractText | Salient visual stimuli enhance theta oscillations and spike-phase locking in the theta band in the primary visual cortex (V1) of mice; however, the detailed mechanisms remain unknown. GABAergic neurons play a vital role in regulating these oscillations. Here, we use optogenetic recordings to tag cell-type-specific neurons in V1 of head-fixed mice and demonstrate that salient visual stimuli facilitate somatostatin (SOM)-expressing neuron responses and firing with theta band oscillations but suppress activities of parvalbumin (PV)-expressing neurons. Furthermore, inactivation of SOM neurons attenuates the enhancement of theta oscillations induced by salient visual stimuli and rhythmic activation of SOM neurons enhances theta oscillations. These results reveal a potential cortical theta oscillation mechanism governed by SOM neurons. |
