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Publication : A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.

First Author  Gauld OM Year  2024
Journal  Neuron PubMed ID  38729150
Mgi Jnum  J:348852 Mgi Id  MGI:7645126
Doi  10.1016/j.neuron.2024.04.015 Citation  Gauld OM, et al. (2024) A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception. Neuron
abstractText  To investigate which activity patterns in sensory cortex are relevant for perceptual decision-making, we combined two-photon calcium imaging and targeted two-photon optogenetics to interrogate barrel cortex activity during perceptual discrimination. We trained mice to discriminate bilateral whisker deflections and report decisions by licking left or right. Two-photon calcium imaging revealed sparse coding of contralateral and ipsilateral whisker input in layer 2/3, with most neurons remaining silent during the task. Activating pyramidal neurons using two-photon holographic photostimulation evoked a perceptual bias that scaled with the number of neurons photostimulated. This effect was dominated by optogenetic activation of non-coding neurons, which did not show sensory or motor-related activity during task performance. Photostimulation also revealed potent recruitment of cortical inhibition during sensory processing, which strongly and preferentially suppressed non-coding neurons. Our results suggest that a pool of non-coding neurons, selectively suppressed by network inhibition during sensory processing, can be recruited to enhance perception.
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