| First Author | Sánchez-Bellot C | Year | 2022 |
| Journal | Nat Commun | Volume | 13 |
| Issue | 1 | Pages | 339 |
| PubMed ID | 35039510 | Mgi Jnum | J:319747 |
| Mgi Id | MGI:6865006 | Doi | 10.1038/s41467-022-27977-7 |
| Citation | Sanchez-Bellot C, et al. (2022) Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour. Nat Commun 13(1):339 |
| abstractText | The decision to either approach or avoid a potentially threatening environment is thought to rely upon the coordinated activity of heterogeneous neural populations in the hippocampus and prefrontal cortex (PFC). However, how this circuitry is organized to flexibly promote both approach or avoidance at different times has remained elusive. Here, we show that the hippocampal projection to PFC is composed of two parallel circuits located in the superficial or deep pyramidal layers of the CA1/subiculum border. These circuits have unique upstream and downstream connectivity, and are differentially active during approach and avoidance behaviour. The superficial population is preferentially connected to widespread PFC inhibitory interneurons, and its activation promotes exploration; while the deep circuit is connected to PFC pyramidal neurons and fast spiking interneurons, and its activation promotes avoidance. Together this provides a mechanism for regulation of behaviour during approach avoidance conflict: through two specialized, parallel circuits that allow bidirectional hippocampal control of PFC. |
