| First Author | Deleuze C | Year | 2019 |
| Journal | PLoS Biol | Volume | 17 |
| Issue | 9 | Pages | e3000419 |
| PubMed ID | 31483783 | Mgi Jnum | J:279446 |
| Mgi Id | MGI:6360794 | Doi | 10.1371/journal.pbio.3000419 |
| Citation | Deleuze C, et al. (2019) Strong preference for autaptic self-connectivity of neocortical PV interneurons facilitates their tuning to gamma-oscillations. PLoS Biol 17(9):e3000419 |
| abstractText | Parvalbumin (PV)-positive interneurons modulate cortical activity through highly specialized connectivity patterns onto excitatory pyramidal neurons (PNs) and other inhibitory cells. PV cells are autoconnected through powerful autapses, but the contribution of this form of fast disinhibition to cortical function is unknown. We found that autaptic transmission represents the most powerful inhibitory input of PV cells in neocortical layer V. Autaptic strength was greater than synaptic strength onto PNs as a result of a larger quantal size, whereas autaptic and heterosynaptic PV-PV synapses differed in the number of release sites. Overall, single-axon autaptic transmission contributed to approximately 40% of the global inhibition (mostly perisomatic) that PV interneurons received. The strength of autaptic transmission modulated the coupling of PV-cell firing with optogenetically induced gamma-oscillations, preventing high-frequency bursts of spikes. Autaptic self-inhibition represents an exceptionally large and fast disinhibitory mechanism, favoring synchronization of PV-cell firing during cognitive-relevant cortical network activity. |
