| First Author | Gallimore CG | Year | 2023 |
| Journal | Cereb Cortex | Volume | 33 |
| Issue | 15 | Pages | 9417-9428 |
| PubMed ID | 37310190 | Mgi Jnum | J:359619 |
| Mgi Id | MGI:7788572 | Doi | 10.1093/cercor/bhad215 |
| Citation | Gallimore CG, et al. (2023) Spatiotemporal dynamics across visual cortical laminae support a predictive coding framework for interpreting mismatch responses. Cereb Cortex 33(15):9417-9428 |
| abstractText | Context modulates neocortical processing of sensory data. Unexpected visual stimuli elicit large responses in primary visual cortex (V1)-a phenomenon known as deviance detection (DD) at the neural level, or "mismatch negativity" (MMN) when measured with EEG. It remains unclear how visual DD/MMN signals emerge across cortical layers, in temporal relation to the onset of deviant stimuli, and with respect to brain oscillations. Here we employed a visual "oddball" sequence-a classic paradigm for studying aberrant DD/MMN in neuropsychiatric populations-and recorded local field potentials in V1 of awake mice with 16-channel multielectrode arrays. Multiunit activity and current source density profiles showed that although basic adaptation to redundant stimuli was present early (50 ms) in layer 4 responses, DD emerged later (150-230 ms) in supragranular layers (L2/3). This DD signal coincided with increased delta/theta (2-7 Hz) and high-gamma (70-80 Hz) oscillations in L2/3 and decreased beta oscillations (26-36 Hz) in L1. These results clarify the neocortical dynamics elicited during an oddball paradigm at a microcircuit level. They are consistent with a predictive coding framework, which posits that predictive suppression is present in cortical feed-back circuits, which synapse in L1, whereas "prediction errors" engage cortical feed-forward processing streams, which emanate from L2/3. |
