| First Author | Li H | Year | 2021 |
| Journal | Cell Rep | Volume | 35 |
| Issue | 3 | Pages | 109003 |
| PubMed ID | 33882311 | Mgi Jnum | J:324646 |
| Mgi Id | MGI:6717070 | Doi | 10.1016/j.celrep.2021.109003 |
| Citation | Li H, et al. (2021) Phasic Off responses of auditory cortex underlie perception of sound duration. Cell Rep 35(3):109003 |
| abstractText | It has been proposed that sound information is separately streamed into onset and offset pathways for parallel processing. However, how offset responses contribute to auditory perception remains unclear. Here, loose-patch and whole-cell recordings in awake mouse primary auditory cortex (A1) reveal that a subset of pyramidal neurons exhibit a transient "Off" response, with its onset tightly time-locked to the sound termination and its frequency tuning similar to that of the transient "On" response. Both responses are characterized by excitation briefly followed by inhibition, with the latter mediated by parvalbumin (PV) inhibitory neurons. Optogenetically manipulating sound-evoked A1 responses at different temporal phases or artificially creating phantom sounds in A1 further reveals that the A1 phasic On and Off responses are critical for perceptual discrimination of sound duration. Our results suggest that perception of sound duration is dependent on precisely encoding its onset and offset timings by phasic On and Off responses. |
