| First Author | Zou Y | Year | 2024 |
| Journal | Neuron | Volume | 112 |
| Issue | 8 | Pages | 1342-1357.e6 |
| PubMed ID | 38359827 | Mgi Jnum | J:349486 |
| Mgi Id | MGI:7623049 | Doi | 10.1016/j.neuron.2024.01.017 |
| Citation | Zou Y, et al. (2024) Cell-type-specific optogenetic fMRI on basal forebrain reveals functional network basis of behavioral preference. Neuron 112(8):1342-1357.e6 |
| abstractText | The basal forebrain (BF) is a complex structure that plays key roles in regulating various brain functions. However, it remains unclear how cholinergic and non-cholinergic BF neurons modulate large-scale functional networks and their relevance in intrinsic and extrinsic behaviors. With an optimized awake mouse optogenetic fMRI approach, we revealed that optogenetic stimulation of four BF neuron types evoked distinct cell-type-specific whole-brain BOLD activations, which could be attributed to BF-originated low-dimensional structural networks. Additionally, optogenetic activation of VGLUT2, ChAT, and PV neurons in the BF modulated the preference for locomotion, exploration, and grooming, respectively. Furthermore, we uncovered the functional network basis of the above BF-modulated behavioral preference through a decoding model linking the BF-modulated BOLD activation, low-dimensional structural networks, and behavioral preference. To summarize, we decoded the functional network basis of differential behavioral preferences with cell-type-specific optogenetic fMRI on the BF and provided an avenue for investigating mouse behaviors from a whole-brain view. |
