| First Author | Foggetti A | Year | 2019 |
| Journal | Cell Rep | Volume | 27 |
| Issue | 13 | Pages | 3725-3732.e5 |
| PubMed ID | 31242406 | Mgi Jnum | J:284080 |
| Mgi Id | MGI:6380881 | Doi | 10.1016/j.celrep.2019.05.098 |
| Citation | Foggetti A, et al. (2019) Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties. Cell Rep 27(13):3725-3732.e5 |
| abstractText | Dendritic spines control synaptic transmission and plasticity by augmenting post-synaptic potentials and providing biochemical compartmentalization. In principal cells, spines cover the dendritic tree at high densities, receive the overwhelming majority of excitatory inputs, and undergo experience-dependent structural re-organization. Although GABAergic interneurons have long been considered to be devoid of spines, a number of studies have reported the sparse existence of spines in interneurons. However, little is known about their organization or function at the cellular and network level. Here, we show that a subset of hippocampal parvalbumin-positive interneurons forms numerous dendritic spines with highly variable densities and input-selective organization. These spines form in areas with reduced perineuronal net sheathing, predispose for plastic changes in protein expression, and show input-specific re-organization after behavioral experience. |
