| First Author | Hu SB | Year | 2003 |
| Journal | J Neuroimmunol | Volume | 135 |
| Issue | 1-2 | Pages | 72-81 |
| PubMed ID | 12576226 | Mgi Jnum | J:105892 |
| Mgi Id | MGI:3616938 | Doi | 10.1016/s0165-5728(02)00442-3 |
| Citation | Hu SB, et al. (2003) Vasopressin receptor 1a-mediated negative regulation of B cell receptor signaling. J Neuroimmunol 135(1-2):72-81 |
| abstractText | We report here a study of T and B cell development and function in mice with disruption of the vasopressin receptor 1a (v1a) gene. Loss of the v1a receptor caused a shift from IgM(high)/IgD(high) to the more mature IgM(low)/IgD(high) B cells, a significantly greater extent of splenic B cells proliferation in response to anti-IgM stimulation, and enhanced IgG1 and IgG2b production in response to immune challenge with T-dependent antigen. B-1 cells were increased in v1a(-/-) mice. In contrast, T cell differentiation and activation were normal in v1a(-/-) mice. Our data identify a novel function for v1a in the periphery as a negative regulator of B cell receptor (BCR) signaling. These data suggest that in addition to its other stress-related effects, vasopressin may also serve as a counter-regulatory restraint upon the immune system during fight or flight situations. |
