| First Author | Du J | Year | 2013 |
| Journal | Proc Natl Acad Sci U S A | Volume | 110 |
| Issue | 46 | Pages | 18501-6 |
| PubMed ID | 24127593 | Mgi Jnum | J:202932 |
| Mgi Id | MGI:5523388 | Doi | 10.1073/pnas.1311193110 |
| Citation | Du J, et al. (2013) Cytosolic reducing power preserves glutamate in retina. Proc Natl Acad Sci U S A 110(46):18501-6 |
| abstractText | Glutamate in neurons is an important excitatory neurotransmitter, but it also is a key metabolite. We investigated how glutamate in a neural tissue is protected from catabolism. Flux analysis using (13)C-labeled fuels revealed that retinas use activities of the malate aspartate shuttle to protect >98% of their glutamate from oxidation in mitochondria. Isolation of glutamate from the oxidative pathway relies on cytosolic NADH/NAD(+), which is influenced by extracellular glucose, lactate, and pyruvate. |
