| Primary Identifier | MGI:3604148 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Prnp-MAPT*P301L)JNPL3Hlmc |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| description | Microinjected into fertilized mouse C57BL/DBA2/SW eggs. |
| molecularNote | The mouse prion protein promoter was used to drive expression of human microtubule-associated protein tau with a P301L substitution. Hemizygous mice mice expressed the protein at levels roughly equivalent to that of endogenous tau. A largely neuronal expression pattern was shown by in situ hybridization, with strongest signals in the cerebellum and hippocampus, followed by the thalamus, hypothalamus, spinal cord, brainstem and cortex. |
