| Primary Identifier | MGI:3604476 | Allele Type | Gene trapped |
| Attribute String | Hypomorph | Gene | Inpp5a |
| Transmission | Germline | Strain of Origin | 129S5/SvEvBrd |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | Lexicon |
| molecularNote | Retroviral gene trap insertion occurred between exons 8 and 9. The insertion truncated the protein after amino acid 215, removing half of the protein including the predicted active site. RT-PCR analysis of P0 mutants confirmed elimination of wild-type mRNA. No truncated protein was detected by Western blot analysis; however, a small amount of normal protein was detected in both homozygous and heterozygous mutants, probably due to a small amount of splicing around the gene trap. |
