| First Author | Butler KL | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Pages | 45593 | PubMed ID | 28358049 |
| Mgi Jnum | J:323496 | Mgi Id | MGI:6878638 |
| Doi | 10.1038/srep45593 | Citation | Butler KL, et al. (2017) CXCR3(+) monocytes/macrophages are required for establishment of pulmonary metastases. Sci Rep 7:45593 |
| abstractText | We present a new foundational role for CXCR3(+) monocytes/macrophages in the process of tumor engraftment in the lung. CXCR3 is associated with monocytic and lymphocytic infiltration of inflamed or tumor-bearing lung. Although the requirement for tumor-expressed CXCR3 in metastatic engraftment has been demonstrated, the role of monocyte-expressed CXCR3 had not been appreciated. In a murine model of metastatic-like melanoma, engraftment was coordinate with CXCR3(+) monocyte/macrophage accumulation in the lungs and was sensitive to pharmacologic inhibition of CXCR3 signaling. Tumor engraftment to lung was impaired in CXCR3(-/-) mice, and transient reconstitution with circulating CXCR3-replete monocytes was sufficient to restore engraftment. These data illustrate the paradoxical pro-tumor role for CXCR3 in lung immunobiology wherein the CXCR3 axis drives both the anti-tumor effector cell chemoattraction and pro-tumor infiltration of the lungs and suggests a potential therapeutic target for lung-tropic metastasizing cancers. |
