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Allele : Hcrtr1<tm1Dgen> hypocretin (orexin) receptor 1; targeted mutation 1, Deltagen

Primary Identifier  MGI:3604598 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Hcrtr1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
Project Collection  Deltagen
molecularNote  A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a gene transcript in brain, spinal cord, pancreas, lymph nodes, skin, urinary bladder, pituitary gland, adrenal gland, small intestine and prostate gland and at lower levels in olfactory bulb, lung, liver, kidney, spleen, bone marrow, gallbladder, stomach, colon, testis, seminal vesicle, coagulating gland, ovary, uterus and white fat; beta-galactosidase expression is detectable in urinary bladder and a few cells in the muscularis, but not in brain, spinal cord, sciatic nerve, eyes, thymus, spleen, lymph nodes, bone marrow, aorta, heart, lung, liver, pancreas, kidney, thyroid gland, pituitary gland, adrenal glands, skeletal muscle, skin, testis, prostate gland, ovary, uterus and cervix.
  • mutations:
  • Disruption caused by insertion of vector
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

6 Publication categories

Trail: Allele