| First Author | Oruganty-Das A | Year | 2012 |
| Journal | Cell Metab | Volume | 16 |
| Issue | 6 | Pages | 789-800 |
| PubMed ID | 23217258 | Mgi Jnum | J:194165 |
| Mgi Id | MGI:5471156 | Doi | 10.1016/j.cmet.2012.11.002 |
| Citation | Oruganty-Das A, et al. (2012) Translational control of mitochondrial energy production mediates neuron morphogenesis. Cell Metab 16(6):789-800 |
| abstractText | Mitochondrial energy production is a tightly regulated process involving the coordinated transcription of several genes, catalysis of a plethora of posttranslational modifications, and the formation of very large molecular supercomplexes. The regulation of mitochondrial activity is particularly important for the brain, which is a high-energy-consuming organ that depends on oxidative phosphorylation to generate ATP. Here we show that brain mitochondrial ATP production is controlled by the cytoplasmic polyadenylation-induced translation of an mRNA encoding NDUFV2, a key mitochondrial protein. Knockout mice lacking the Cytoplasmic Polyadenylation Element Binding protein 1 (CPEB1) have brain-specific dysfunctional mitochondria and reduced ATP levels, which is due to defective polyadenylation-induced translation of electron transport chain complex I protein NDUFV2 mRNA. This reduced ATP results in defective dendrite morphogenesis of hippocampal neurons both in vitro and in vivo. These and other results demonstrate that CPEB1 control of mitochondrial activity is essential for normal brain development. |
