| First Author | Bonner JJ | Year | 1982 |
| Journal | Teratology | Volume | 26 |
| Issue | 2 | Pages | 213-6 |
| PubMed ID | 7157197 | Mgi Jnum | J:6974 |
| Mgi Id | MGI:55445 | Doi | 10.1002/tera.1420260214 |
| Citation | Bonner JJ, et al. (1982) Backcross test demonstrates the linkage of glucocorticoid-induced cleft palate susceptibility to H-2. Teratology 26(2):213-6 |
| abstractText | Data in this report demonstrate a linkage between glucocorticoid-induced cleft palate susceptibility and H-2. B10.A X C57BL/10F1 females were backcrossed to C57BL/10 males. Cleft palate was induced in the BC1 fetuses by giving pregnant females 80 mg/kg of dexamethasone intraperitoneally (IP) on day 12 of gestation. The H-2a/b haplotype was detected on day 18 BC1 fetal spleen cells with an indirect immunofluorescent labeling technique. Fetuses without antigen H-2Kk were H-2b/b . H-2a/b fetuses had a cleft palate frequency of 29%; 11% of the H-2b/b fetuses had cleft palate (P less than .01), demonstrating that the higher susceptibility to cleft palate segregates with the H-2a halotype. |
