Primary Identifier | MGI:3607931 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Ret |
Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A cDNA fragment encoding the intracellular portion of the human RET9 isoform was fused in-frame with mouse exon 11 immediately downstream of the transmembrane domain-coding region. The inserted cDNA contained substitutions changing the amino acids M and S at the start of the Ret51 specific sequence to R and I, and was followed by a floxed PGK-neo cassette. |