| Primary Identifier | MGI:3609979 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Vegfb |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin resistance cassette was inserted via homologous recombimation to replace part of exons 3 and 4. The deleted sequence was about 330 bp in length and encoded the VEGF homology domain, including 7 of the 8 invariant cystein residues involved in intermolecular and intramolecular disulfide bonding and the VEGFR-1 binding epitope. Western blot failed to detect protein in mutant heart and muscle. |
