| First Author | Avila A | Year | 2013 |
| Journal | Cell Rep | Volume | 4 |
| Issue | 4 | Pages | 738-50 |
| PubMed ID | 23954789 | Mgi Jnum | J:202763 |
| Mgi Id | MGI:5521423 | Doi | 10.1016/j.celrep.2013.07.016 |
| Citation | Avila A, et al. (2013) Glycine receptor alpha2 subunit activation promotes cortical interneuron migration. Cell Rep 4(4):738-50 |
| abstractText | Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the alpha2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR alpha2 activation that control cortical tangential migration during embryogenesis. |
