| First Author | Faulkes DJ | Year | 2004 |
| Journal | Neuroreport | Volume | 15 |
| Issue | 9 | Pages | 1421-5 |
| PubMed ID | 15194866 | Mgi Jnum | J:103665 |
| Mgi Id | MGI:3610594 | Doi | 10.1097/01.wnr.0000129371.81377.05 |
| Citation | Faulkes DJ, et al. (2004) Distinct domains of Brn-3a regulate apoptosis and neurite outgrowth in vivo. Neuroreport 15(9):1421-5 |
| abstractText | The Brn-3a transcription factor is critical for the normal development of the nervous system, promoting both neuronal survival and neurite outgrowth. By manipulating the Brn-3a gene in intact mice, we show that these two functions are separately controlled with an N-terminal domain being essential for neuronal survival, whereas the POU domain is essential for neurite outgrowth. Hence the two naturally occurring forms of Brn-3a, which either contain or lack the N-terminal domain, are likely to play distinct roles in the nervous system. |
