Primary Identifier | MGI:3614430 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence, Null/knockout | Gene | Ret |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was designed to insert human isoform RET51 containing a replacement of residues 1063-1072 with residues 1063-1072 of human isoform RET9. This resulted in an allele similar to Rettm2(RET)Jmi, but has the C-terminus of RET51 containing a Y1096 not present in RET9. Endogenous transcript was not detected in mutants; however, transcript from the inserted human RET9 sequence was detected. |