| First Author | Králová J | Year | 1979 |
| Journal | J Immunogenet | Volume | 6 |
| Issue | 6 | Pages | 429-38 |
| PubMed ID | 521667 | Mgi Jnum | J:6255 |
| Mgi Id | MGI:54732 | Doi | 10.1111/j.1744-313x.1979.tb00697.x |
| Citation | Kralova J, et al. (1979) H-Y antigen: genetic control of the expression as detected by host-versus-graft popliteal lymph node enlargement assay maps between the T and H-2 complexes. J Immunogenet 6(6):429-38 |
| abstractText | We are using the terms 'low' and 'high' expression when the H-Y antigen on thymocytes of mouse parental strains is, respectively, weakly and strongly immunogenic for F1 hybrids in a host-versus-graft popliteal lymph node enlargement assay. Using this assay we attempted to locate the genetic factor(s) responsible for the control of H-Y expression within chromosome 17 since our previous study indicated linkage with the H-2 complex. We produced to this aim recombinants from (B10.T X C3H/Di)F1 hybrids where crossing over took place between H-2 and T complexes. In this way we were able to locate a gene denoted Hye (for H-Y expression) whose 'high' and 'low' alleles originated, respectively, from the B10 and C3H/Di strains. In the recombinants, the expression did not follow the H-2 haplotype, but obviously depended on the position of crossing over between H-2 and T. This pointed to the Hye gene mapping proximally from the H-2 complex. |
