| First Author | Pramfalk C | Year | 2014 |
| Journal | J Lipid Res | Volume | 55 |
| Issue | 4 | Pages | 709-17 |
| PubMed ID | 24478032 | Mgi Jnum | J:208780 |
| Mgi Id | MGI:5565027 | Doi | 10.1194/jlr.M045922 |
| Citation | Pramfalk C, et al. (2014) TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2. J Lipid Res 55(4):709-17 |
| abstractText | Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting factor 1 (Tgif1) to function as an important repressor of SOAT2. Tgif1 could also block the induction of the SOAT2 promoter activity by hepatocyte nuclear factor 1alpha and 4alpha. Women have approximately 30% higher hepatic TGIF1 mRNA compared with men. Depletion of Tgif1 in mice increased the hepatic Soat2 expression and resulted in higher hepatic lipid accumulation and plasma cholesterol levels. Tgif1 is a new player in human cholesterol metabolism. |
