| First Author | Makino M | Year | 1995 |
| Journal | Scand J Immunol | Volume | 42 |
| Issue | 3 | Pages | 368-72 |
| PubMed ID | 7660069 | Mgi Jnum | J:29618 |
| Mgi Id | MGI:77145 | Doi | 10.1111/j.1365-3083.1995.tb03669.x |
| Citation | Makino M, et al. (1995) Impact of MHC class I gene on resistance to murine AIDS. Scand J Immunol 42(3):368-72 |
| abstractText | Development of murine AIDS in mice following infection with LP-BM5 murine leukaemia virus (MuLV) is highly strain dependent, with strain differences determined by genes within and outside H-2. Among H-2 genes, the Dd gene is the most closely associated with resistance to LP-BM5 MuLV infection. However, the Dd-mediated resistance is highly influenced by outside H-2 genes, i.e. A lineage strains are more resistant than mice strains of B6/B10 lineage. In this study, the mice having BALB background were analysed and, similarly to A lineage mice, only Dd gene products were found to be required to provide resistance to LP-BM5 MuLV infection. Furthermore, BALB/c Kh mice bearing both Dd and Ld genes clearly showed obviously higher resistance than BALB/c-H-2dm2 mice solely having the Dd gene. In addition, in the long-term observation of the effect of the Dd gene on B6/B10 background mice, D8 mice having the Dd gene as a transgene and expressing a high level Dd gene product showed higher resistance than naturally recombinant B10.A(18R) mice. These results suggest that the MAIDS resistance associated with the D end loci is dependent on the level of expression of an MHC class I gene. |
