| Primary Identifier | MGI:3617607 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(TcraCl1,TcrbCl1)1Shrm |
| Strain of Origin | B10.D2-Hc<1> H2<d> H2-T18<c>/nSnJ | Is Recombinase | false |
| Is Wild Type | false |
| description | CD8+ T cells bearing this transgene, when transferred to mice that develop pancreatic tumors expressing influenza virus HA, can be induced to exhibit both effector function and antitumor activity only if HA-responsive CD4+ T cells are co-transferred and the mice are subsequently infected with influenza virus. : J:97745 |
| molecularNote | The transgene encodes a low avidity T cell receptor (TCR) that recognizes the influenza virus hemagglutinin (HA) epitope HA518-526 in the context of the H2-Kd MHC class I molecule. The rearranged Tcra and Tcrb genes, which have joined Valpha1/Jalpha11 and Vbeta8.2/D/Jbeta2.4, respectively, were amplified from cytotoxic T lymphocyte (CTL) clone 1. Clone 1 was derived from a transgenic B10.D2 mouse that expressed influenza virus HA as a self-antigen in pancreatic beta cells, which resulted in production of lower-avidity TCRs than those made by wild-type B10.D2 mice after infection with influenza virus strain A/PR/8/32. |
