| Primary Identifier | MGI:3620139 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(CTSG-RARA/PML)2683Ley |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| description | This is one of 4 germline-transmitting lines expressing this transgenic construct that are mentioned in J:59080, of which 2 are characterized in detail (but not distinguished from one another). Leukemia in the doubly transgenic mice described above is a model for acute promyelocytic leukemia; see OMIM *102578: ACUTE PROMYELOCYTIC LEUKEMIA, INDUCER OF; PML |
| molecularNote | The functional cDNA coding sequence is derived from the breakpoint cluster region 3 (bcr-3) isoform transcript of the RARA/PML fusion gene resulting from the characteristic t(15;17)(q22;q11.2-q12) translocation associated with ~90% of human cases of acute promyelocytic leukemia (APML). The bcr-3 isoform of the chimeric gene joins exon 2 of the retinoic acid receptor alpha (RARA) gene in-frame to PML exons 4-8. Expression is targeted specifically to early myeloid-lineage cells by the promoter and 5' regulatory elements of the human cathepsin G gene. |
