| First Author | Saha B | Year | 2012 |
| Journal | J Neurosci | Volume | 32 |
| Issue | 47 | Pages | 16892-905 |
| PubMed ID | 23175841 | Mgi Jnum | J:190014 |
| Mgi Id | MGI:5447802 | Doi | 10.1523/JNEUROSCI.0344-12.2012 |
| Citation | Saha B, et al. (2012) Plexin-b2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular zone. J Neurosci 32(47):16892-905 |
| abstractText | In the postnatal forebrain, the subventricular zone (SVZ) contains a pool of undifferentiated cells, which proliferate and migrate along the rostral migratory stream (RMS) to the olfactory bulb and differentiate into granule cells and periglomerular cells. Plexin-B2 is a semaphorin receptor previously known to act on neuronal proliferation in the embryonic brain and neuronal migration in the cerebellum. We show here that, in the postnatal and adult CNS, Plexin-B2 is expressed in the subventricular zone lining the telencephalic ventricles and in the rostral migratory stream. We analyzed Plxnb2(-/-) mice and found that there is a marked reduction in the proliferation of SVZ cells in the mutant. Plexin-B2 expression is downregulated in the olfactory bulb as interneurons initiate radial migration. BrdU labeling and GFP electroporation into postnatal SVZ, in addition to time-lapse videomicroscopy, revealed that neuroblasts deficient for Plexin-B2 migrate faster than control ones and leave the RMS more rapidly. Overall, these results show that Plexin-B2 plays a role in postnatal neurogenesis and in the migration of SVZ-derived neuroblasts. |
